Human primary hepatocytes, isolated from liver tissue, retain key metabolic functions for drug metabolism, toxicity, ADME & CYP studies. Their human origin offers relevant data for pharma/toxicology research vs cell...
Sprague Dawley (SD) rats are a well-characterized outbred strain widely used in preclinical research for pharmacology, toxicology, pharmacokinetics, neuroscience, and metabolic studies due to their adaptability, size, and extensive historical...
CD-1 is an outbred mouse strain used in preclinical pharmacology, toxicology, and biomedical research. Its genetic diversity aids studying varied biological responses for toxicity, safety, PK/PD, and efficacy studies. Model...
Human Intestinal S9 fraction is a subcellular prep from human gut tissue with microsomal + cytosolic enzymes. It models intestinal first-pass metabolism of oral drugs, supporting studies of metabolic stability,...
Human S9 fractions (liver/intestinal, pooled/individual) contain microsomal + cytosolic enzymes for Phase I/II metabolism. Ideal for stability, metabolite ID, DDI, toxicology & bioavailability studies in early drug discovery. Complementary to...
Beagle liver S9 fractions are in vitro models from canine liver with microsomal (e.g. CYP) and cytosolic enzymes. Used in preclinical research for metabolic stability, metabolite profiling, DMPK, toxicology, and...
Wistar rat S9 fraction is a liver subcellular prep with microsomal + cytosolic enzymes for Phase I/II drug metabolism studies. Used for metabolic stability, metabolite profiling & biotransformation, it bridges...
Sprague-Dawley (SD) rats are versatile outbred models widely used in pharmacology, toxicology, disease modeling, and regenerative medicine. They are often combined with primary hepatocytes, microsomes, and S9 fractions to study...
CD-1 mice are outbred Swiss-origin stock with genetic diversity, strong reproduction & adaptability. Used in toxicology, pharmacology, drug development, reproductive & developmental research for broader biological responses vs. inbred strains.
Human liver microsomes are ER-derived vesicles rich in CYP and other enzymes, used in vitro to assess drug metabolic stability, metabolite formation, clearance, and CYP-mediated interactions in early ADME studies—simple,...
